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KMID : 0388019920030010048
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Korean Journal Gynecologic Oncology and Colposcopy
1992 Volume.3 No. 1 p.48 ~ p.60
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The Prognostic Significance of the Half-life of Serum CA 125 during Therapy in Epithelial Ovarian Carcinoma
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박종설
김경태/정성로/황윤영/문형/김두상
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Abstract
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Twenty-eight patients with epithelial ovarian carcinoma were serially monitored with the CA 125 antigenic determinant to assess the prognostic of the half-life of serum CA 125 during therapy. The end points of the analysis were clinically and
surgically
free of disease after completion of cytoreductive chemotherapy and 3 year actuarial survival. Patients with postoperative residual tumor of≤2 cm and a serum CA 125 halflife of＜ 20 hays had a significantly higher response rate to chemotherapy,
as
compared to for patients with potoperative residual tumor＞2 cm and a half-life of more 20 davs(86% vs 0%). The clinical remission rate was 73% or 20% for patients with a serum CA 125 half-life of〈20 or〉40 days. However, the chance of achieving
clinically and surgically free of disease was 53% or 20% respectively for patients with a serum CA 125 half-life of ＜20 ro＞ 40 days. Among 14 patients who were clinically and surgically free of disease after completion of cytoreductive
chemotherapy.
13(93%) patients had a serum CA 125 half-life of ＜20 days and stayed low level. A CA 125 half-life of ＜20 days or＞ 40 days appears to identity patients with a good or poor prognosis, the three-year actuarial survival being 63% and 0%
respectively.
Therefore, the half-life of serum CA 125 during treatment appears to be critical prognostic predictor of response to therapy. It is highly suggested that those patients with a half-life＜ 20 days have a good chance of achieving a complete
response
and a
prolonged progression-free survival, whereas those with raised CA 125 or any with a CA 125 half-life＞ 40 days after two or three courses of treatment should have their treatment modified since they would appear to have a very poor prognosis.
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KEYWORD
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